Teaching plan for the course unit (Short version)
Català English Close

 

General information

 

Course unit name: Pharmacology

Course unit code: 365584

Academic year: 2021-2022

Coordinator: Patricia Gasso Astorga

Department: Department of Basic Clinical Practice

Credits: 6

Single program: S

Estimated learning time

Total number of hours 150

 

Face-to-face and/or online activities

56

	-  Lecture	Face-to-face		31
	-  Group tutorial	Face-to-face		3
	-  IT-based class	Face-to-face		10
	-  Laboratory session	Face-to-face		6
	-  Student presentation and discussion	Face-to-face		6

Supervised project

44

Independent learning

50

Learning objectives

Referring to knowledge Know the fundamental aspects of the properties and the mechanisms of action of drugs in the various pharmacological groups on which rational drug therapy is based. Know the physicochemical characteristics of drugs and the main pharmacokinetic parameters, their definition and calculation. Know the bases of drug interactions and adverse reactions. Within each pharmacological group, know the main characteristics of the most common drugs and their main therapeutic applications. Know the main experimental models for the study and development of new drugs.

 

 

Teaching blocks

 

1. Basic principles of pharmacology

*  

• Pharmacodynamics: how drugs work
• Introduction to pharmacokinetics. Absorption and routes of administration. Distribution, metabolism. Excretion
• Key aspects that can modify drug response

2. Basic principles of experimental pharmacology

*  

• The experimental animal in pharmacology
• Types of experimental animals
• Introduction to current legislation
• Anaesthesia

3. Pharmacology of the autonomic nervous system

*  

• Pharmacology of the histaminergic receptor
• Pharmacology of the cholinergic receptor
• Effects mediated by nicotinic receptors
• Pharmacology of the adrenergic receptor
• Pharmacology of the dopaminergic receptor

4. Pharmacology of the respiratory system

*  

• Drugs used in the treatment of respiratory diseases

5. Pharmacology of inflammation and pain

*  

• Pharmacology of lipid mediators. Icosanoids
• Analgesic, antipyretic, anti-inflammatory drugs
• Opioid analgesic drugs

6. Pharmacology of the central nervous system

*  

• Anxiolytics and hypnotics. Barbiturates
• Pharmacology of the GABAergic receptor. Benzodiazepines
• Pharmacology of the depressive state. Anti-maniacs
• Antiepileptics and antiparkinsonian drugs

7. Cardiovascular and renal pharmacology

*  

• Pharmacology of vascular tone. Mediators involved
• Pharmacological regulation of cardiac function
• Pharmacological modulation of renal function
• Lipid-lowering agents

8. Pharmacology of gastric secretion

*  

• Antisecretors, protectors of the gastric mucosa, antiemetics. Pharmacology of gastrointestinal motility

9. Communicative oral practice sessions

*  

• Contraceptives
• Pharmacology and pharmaceutical industry
• Drugs of abuse. Effects on health
• Toxicology
• Drug development
• Pharmacogenetics

10. Lab sessions

*  

• Isolated organ bath. Lab session in which a fragment of mouse ileum is used to prepare the isolated organ bath in which different molecules are tested to assess their ability to stimulate contraction.
• Medicines and pharmaceutical forms. The combination of a computer program and a sample of pharmaceutical forms allows students to match the samples with their nomenclature. Each of these forms is studied in the context of a route of administration and a clinical application. Students also prepare a master formula in the laboratory.
• Clinical cases. A broad discussion is undertaken of aspects related to pharmacological treatment, including polymedication, therapeutic compliance, and or pharmacological and food interactions, so as to allow students to address three different clinical cases.
• Toxicology. Methods and calculations for the evaluation of pharmacological toxicity
• Determination of the effects of drugs at the cardiovascular level. A study is made of the effect of drugs on blood pressure and heart rate.
• Pharmacological databases. Search databases to evaluate the placebo effect.
• Pharmacokinetic calculations. A computer program is used for pharmacokinetic calculations and its usefulness in solving different clinical cases is demonstrated.

 

 

Reading and study resources

Consulteu la disponibilitat a CERCABIB

Book

Rang HD. Farmacología : Rang y Dale : 8ª ed. Barcelona : Elsevier España; 2016.

Brenner G, Stevens C. Farmacología básica. 5ª ed, Elsevier, 2019.

Florez J. Farmacología humana. 6ª ed. Barcelona: Elsevier Masson; 2014.

Page C, Battista E. Lo esencial en Farmacología. 5ª ed. Elsevier; 2019.

Goodman & Gilman. The Pharmacological basis of Therapeutics. 13a ed.  México: McGraw-Hill Interamericana; 2017.

Velazquez. Manual de Farmacología básica y clínica. 19a ed. México: Editorial Médica Panamericana; 2017