Teaching plan for the course unit

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General information

 

Course unit name: Molecular Endocrinology and Cell Signalling

Course unit code: 365594

Academic year: 2021-2022

Coordinator: Jose Luis Rosa Lopez

Department: Department of Physiological Sciences

Credits: 6

Single program: S

 

 

Estimated learning time

Total number of hours 150

 

Face-to-face and/or online activities

60

 

-  Lecture

Face-to-face and online

 

30

 

-  Group tutorial

Face-to-face

 

2

 

-  IT-based class

Face-to-face

 

12

 

-  Seminar

Face-to-face and online

 

16

Supervised project

40

Independent learning

50

 

 

Learning objectives

 

Referring to knowledge

• Know the main elements and mechanisms of molecular endocrinology.

• Know the basic concepts of regulation.

• Know the elements and mechanisms involved in cell signalling pathways.

• Understand how the signalling pathways that control the coordinated cellular response function and how they are integrated.

 

Referring to skills, abilities

• Be able to work on numerical data on hormone receptor binding kinetics, determine corresponding parameters and draw relevant conclusions.

• Be able to apply different methods of hormone quantification and evaluate their respective strengths and limitations in each case.

• Be able to integrate and relate knowledge of molecular and regulatory mechanisms as taught on the course.

• Interpret experimental data and extract conclusions from them.

 

 

Teaching blocks

 

1. Molecular endocrinology and cell signalling

*  1. Basic concepts of regulation

1.1. Principles of cell signalling

1.2. Hormone-receptor interaction

1.3. Regulation of enzyme activity and gene expression

 

2. Molecular signalling mechanisms

2.1. Nuclear receptor signalling

2.2. Signalling pathways of receptors with own or associated tyrosine kinase activity

2.3. Signalling pathways of receptors with serine/threonine kinase activity

2.4. Signal transduction generated by G protein-coupled receptors

2.5. Signalling pathways generated by cAMP and cGMP

2.6. Signalling pathways generated by phospholipids and calcium

2.7. Signalling pathways generated by proteolysis

2.8. Signalling pathways of receptors with death domains and TIR

 

3. Molecular endocrinology

3.1. Integration of hormone signalling

3.2. New perspectives in molecular endocrinology

 

 

 

 

Reading and study resources

Consulteu la disponibilitat a CERCABIB

Book

- ALBERTS, B. [et al.] Biología molecular de la célula: sexta edición. Barcelona: Omega, cop. 2016 [També, 6th ed., 2015, en anglès]   

- KOVACS, W.J.; OJEDA, S.R. (ed.). Textbook of endocrine phisiology. 6th ed. Oxford: Oxford University Press, c2012  

- KRAUSS, G. Biochemistry of signal transduction and regulation. 5th ed. Weinheim: Wiley-VCH, [2014]  

- LODISH, H [et al.] Molecular Cell Biology. 8ª ed. 2016. Freeman New York.

- MEISENBERG, G.; SIMONS, W.H. Principios de Bioquímica Médica. 4ª edición. 2018. Eselvier España, S.L.U. [També, 4th ed., 2017, en anglès]

- NELSON, D.L.; COX, M.M. Principios de bioquímica [de] Lehninger: sexta edición. Barcelona: Omega, 2015 [També, 6th ed., 2013, en anglès]   

Dee Unglaub Silverthorn. Human Physiology: an integrated approach. 8th ed. Editorial: Pearson College Div (2018).