Teaching plan for the course unit



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General information


Course unit name: Advanced Genetic Analysis and Functional Genomics

Course unit code: 568761

Academic year: 2021-2022

Coordinator: Montserrat Corominas Guiu

Department: Department of Genetics, Microbiology and Statistics

Credits: 5

Single program: S



Estimated learning time

Total number of hours 125


Face-to-face and/or online activities



-  Lecture

Face-to-face and online




-  Problem-solving class





-  Seminar




Supervised project


Independent learning




Competences to be gained during study


Basic competences

— Knowledge forming the basis of original thinking in the development or application of ideas, typically in a research context.

— Capacity to apply the acquired knowledge to problem-solving in new or relatively unknown environments within broader (or multidisciplinary) contexts related to the field of study.

— Capacity to integrate knowledge and tackle the complexity of formulating judgments based on incomplete or limited information, taking due consideration of the social and ethical responsibilities involved in applying knowledge and making judgments.

— Capacity to communicate conclusions, judgments and the grounds on which they have been reached to specialist and non-specialist audiences in a clear and unambiguous manner.

— Skills to enable lifelong self-directed and independent learning.


General competences

— Capacity to structure a reasoned discourse in a logical and rational manner, to discuss any scientific topic in front of diverse audiences.

— Capacity for critical, logical and creative thought. Capacity for analysis and synthesis.

— Capacity for interaction and transfer activities with their environment.

— Capacity to work in groups and to collaborate with other researchers.

— Capacity to read and critically interpret scientific publications related to the subject, mainly in English, and to be able to design, write and defend a research project.


Specific competences

— Ability to correctly choose between the various basic techniques of cellular and genetic analysis in order to analyse the structure, regulation, function and evolution of genes and genomes.

— Ability to analyse the impact on cell function of genetic and epigenetic mechanisms that control cellular memory.

— Ability to analyse the human genome as a model from which to infer gene structure, function and regulation.





Learning objectives


Referring to knowledge

The overall aim of the course is to provide theoretical skills concerning advanced genetics as well as in-depth knowledge about the structure, organisation and expression of genomes. 

After completion of the course, the student should be able to:

  • Understand the logic behind genetic analyses and the type of information they provide
  • Describe and differentiate between large-scale analyses at different levels, including genomics, transcriptomics, proteomics and systems biology
  • Describe and understand when to use a broad spectrum of functional genomics methods, and be updated on current technical developments within the genomics and functional genomics fields
  • Critically examine research reports and publications dealing with genomics and functional genomics, and be able to suggest alternative interpretations and relevant follow-up experiments



Teaching blocks


1. Advanced genetic analysis

*  Introduction to genetic analysis
Mutant production and techniques for mutagenesis

Transposable elements for mutagenesis, transgenesis and phenotype rescue

Mutant identification and mapping

Genome engineering for genetic analysis

Sequence exchange between repeats

Model organisms for genetic analysis

Mutant banks and genetic resources

Classification of mutants

Gene nomenclature across model systems

Mitotic segregation and recombination

Genetic mosaics

Recombination and transactivation systems

Forward and reverse genetic screens


2. Functional genomics

*  Introduction to functional genomics
Sequencing technologies

Genomics of gene expression and its regulation

Analysis of DNA-protein and RNA-protein interactions

Genome structure and architecture (3D genome)


RNAi screens



Teaching methods and general organization


Face-to-face education
It consists of theoretical classes and seminars.
The student has access to the material used in these classes through the Virtual Campus of the UB. It also includes lectures given by invited guest professors in different aspects of genetics and functional genomics.
​Active participation is not only encouraged but also requested.

Independent learning

Consists of reading the recommended articles, watching related videos and searching databases.

This activity must be reflected in the active participation in class and research seminars.


Professors are available for consultation on doubts or questions related to the subject, both in person during office hours or via e-mail.



Official assessment of learning outcomes


Evaluation criteria and procedures:
Written exam based on the information discussed during the theoretical classes and seminars.

On line homework assignments and active participation during seminar and practicals of problems sessions.

To pass the subject, students must attend at least 80% of the classes.