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Teaching plan for the course unit
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Course unit name: Regeneration and Stem Cells
Course unit code: 568773
Academic year: 2021-2022
Coordinator: Francesc Cebria Sanchez
Department: Department of Genetics, Microbiology and Statistics
Credits: 2,5
Single program: S
Very important detail: Classes may be taught in English.
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Estimated learning time
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Total number of hours 62.5
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Face-to-face and/or online activities
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16
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- Lecture
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Face-to-face
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16
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Teachers are available for consultation on any doubts or questions related to the subject, both in person during office hours or at any time via email.
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Competences to be gained during study
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Competences to be gained during study
Basic competences
Knowledge forming the basis of original thinking in the development and/or application of ideas, typically in a research context.
— Capacity to apply acquired knowledge and solve problems in new or unfamiliar environments within broader or multidisciplinary contexts related to the area of study.
— Capacity to integrate knowledge and tackle the complexity of formulating judgements based on incomplete or limited information, taking due consideration of the social and ethical responsibilities involved in applying knowledge and making judgements.
— Capacity to communicate knowledge and conclusions and the grounds on which they have been reached to specialist and non-specialist audiences in a clear and unambiguous manner.
— Skills to enable lifelong self-directed and independent learning.
General competences
— Capacity to structure a reasoned discourse in a logical and rational manner, to discuss any scientific topic in front of larger audiences.
— Capacity for critical, logical and creative thought. Capacity for analysis and synthesis.
— Capacity for interaction and transfer activities with their environment.
— Capacity to work in groups and to collaborate with other researchers.
— Capacity to read and critically interpret scientific publications related to the subject, mainly in English, and to be able to design, write and defend a research project.
Specific competences
— Capacity for the proposal of methodological designs for assessing genetic diversity based on knowledge of the evolutionary processes that generate this diversity.
— Ability to process and interpret genomic data resulting from gene expression analysis and massive genome sequencing. Skill in the use of scientific databases and bioinformatics tools used to access available genomic annotations.
— Ability to apply knowledge on the origins and functions of stem cells during cellular regeneration and reprogramming in order to generate iPS cells and organoids to devise applications for them in regenerative medicine.
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Referring to knowledge
Learning objectives
Referring to knowledge
The main objective of this course is to understand the various classic models of regeneration at cellular, molecular and genetic levels, with particular emphasis on the role of stem cells as well as the processes involved in maintaining a given state, i.e. transdetermination and transdifferentiation. It also provides an explanation of the different methods and strategies for analysing the lineage and potential uses of stem cells. Topics include the action of genes responsible for the reprogramming of specific or differentiated cells into pluripotent cells (induced pluripotent stem cells or iPS cells). The generation of organoids and their multiple applications in the field of regenerative medicine. Finally, a peculiar case is studied, that of cancer stem cells.
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1.
Teaching Blocs
* Specialized seminars and discussion of scientific papers and book chapters of a general nature presented throughout the course, and establishment of general "principles" and "rules" regarding regeneration and stem cells
1.1.
Introduction to stem cells and regeneration
1.2.
Pluripotent stem cells-based regeneration
1.3.
Dedifferentiation- and transdifferentiation-based regeneration
1.4.
Regeneration in mammals
1.6.
Organoids in regenerative medicine
1.8.
Final discussion and conclusions
Teaching methods and general organization
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Teaching methods and general organization
Face-to-face learning activities
Face-to-face learning activities consist of theory classes, seminars and the analysis of scientific papers. They may also include one or two lectures given by specialist guest lecturers.
Independent learning activities
Independent learning comprises recommended reading, to ensure full understanding of the concepts presented in class. It also includes reading the specific papers indicated by the teacher for later discussion in class.
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Official assessment of learning outcomes
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Assessment criteria and procedures Written examination based on:
— Concepts explained in class.
— Lectures given by guest lecturers.
— Scientific papers analysed and discussed throughout the course.
The degree of active participation in all classes and general discussions will also be taken into account.
In order to pass the course, at least 70% of attendance is required, as well as passing the written examination.
Very important detail: Classes may be taught in English.
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Reading and study resources
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Consulteu la disponibilitat a CERCABIB
Book
Regeneration. Chapter 13. Wolpert L. Principles of development. 5th ed. Oxford : Oxford University Press, 2015 
[També, 3a ed., 2010, en castellą]
Regeneration, Chapter 22. Barresi & Gilbert. Developmental Biology. 12th ed. Oxford: Oxford University Press, 2020
Stem cells, Chapter 5. Barresi & Gilbert. Developmental Biology. 12th ed. Oxford: Oxford University Press, 2020
Article
Saló E. BioEssays 28, 546-559 (2006). Daniel E. Wagner, Irving E. Wang, Peter W. Reddien Science 332, 811 (2011) 
Martin Kragl, Dunja Knapp, Eugen Nacu, Shahryar Khattak, Malcolm Maden, Hans Henning Epperlein& Elly M. Tanaka. Nature 460, 60-65 (2009). 
Nelson Fausto,1 Jean S. Campbell,1 and Kimberly J. Riehle1,2 (2006). Liver Regeneration. Hepatology, Vol. 43, No. 2, Suppl. 1 
Reprogramació nuclear: Gurdon, J.B & Melton, D.A. Nuclear reprogramming in cells. Science 322, 1811-1815 (2008). 
Daniel E. Wagner, Irving E. Wang, Peter W. Josien C. van Wolfswinkel, Daniel E. Wagner and Peter W. Reddien Cell Stem Cell 15, 1–14 (2014). 