Teaching plan for the course unit

 

 

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General information

 

Course unit name: Regeneration and Stem Cells

Course unit code: 568773

Academic year: 2021-2022

Coordinator: Francesc Cebria Sanchez

Department: Department of Genetics, Microbiology and Statistics

Credits: 2,5

Single program: S

 

 

Prior considerations

 

Very important detail: Classes may be taught in English.

 

 

Estimated learning time

Total number of hours 62.5

 

Face-to-face and/or online activities

16

 

-  Lecture

Face-to-face

 

16

Supervised project

16.5

Independent learning

30

 

 

Recommendations

 

Teachers are available for consultation on any doubts or questions related to the subject, both in person during office hours or at any time via email.

 

 

Competences to be gained during study

 

Competences to be gained during study
 

Basic competences

Knowledge forming the basis of original thinking in the development and/or application of ideas, typically in a research context.

— Capacity to apply acquired knowledge and solve problems in new or unfamiliar environments within broader or multidisciplinary contexts related to the area of study.

— Capacity to integrate knowledge and tackle the complexity of formulating judgements based on incomplete or limited information, taking due consideration of the social and ethical responsibilities involved in applying knowledge and making judgements.

— Capacity to communicate knowledge and conclusions and the grounds on which they have been reached to specialist and non-specialist audiences in a clear and unambiguous manner.

— Skills to enable lifelong self-directed and independent learning.

General competences

— Capacity to structure a reasoned discourse in a logical and rational manner, to discuss any scientific topic in front of larger audiences.

— Capacity for critical, logical and creative thought. Capacity for analysis and synthesis.

— Capacity for interaction and transfer activities with their environment.

— Capacity to work in groups and to collaborate with other researchers.

— Capacity to read and critically interpret scientific publications related to the subject, mainly in English, and to be able to design, write and defend a research project.

 

Specific competences

— Capacity for the proposal of methodological designs for assessing genetic diversity based on knowledge of the evolutionary processes that generate this diversity.

— Ability to process and interpret genomic data resulting from gene expression analysis and massive genome sequencing. Skill in the use of scientific databases and bioinformatics tools used to access available genomic annotations.

— Ability to apply knowledge on the origins and functions of stem cells during cellular regeneration and reprogramming in order to generate iPS cells and organoids to devise applications for them in regenerative medicine.

 

 

 

 

Learning objectives

 

Referring to knowledge

Learning objectives
 

Referring to knowledge

The main objective of this course is to understand the various classic models of regeneration at cellular, molecular and genetic levels, with particular emphasis on the role of stem cells as well as the processes involved in maintaining a given state, i.e. transdetermination and transdifferentiation. It also provides an explanation of the different methods and strategies for analysing the lineage and potential uses of stem cells. Topics include the action of genes responsible for the reprogramming of specific or differentiated cells into pluripotent cells (induced pluripotent stem cells or iPS cells). The generation of organoids and their multiple applications in the field of regenerative medicine. Finally, a peculiar case is studied, that of cancer stem cells.

 

 

Teaching blocks

 

1. Teaching Blocs

*  Specialized seminars and discussion of scientific papers and book chapters of a general nature presented throughout the course, and establishment of general "principles" and "rules" regarding regeneration and stem cells

1.1. Introduction to stem cells and regeneration

1.2. Pluripotent stem cells-based regeneration

1.3. Dedifferentiation- and transdifferentiation-based regeneration

1.4. Regeneration in mammals

1.5. Cell reprogramming

1.6. Organoids in regenerative medicine

1.7. Cancer stem cells

1.8. Final discussion and conclusions

 

 

Teaching methods and general organization

 

 

Teaching methods and general organization

 

Face-to-face learning activities

Face-to-face learning activities consist of theory classes, seminars and the analysis of scientific papers. They may also include one or two lectures given by specialist guest lecturers.

 

Independent learning activities

Independent learning comprises recommended reading, to ensure full understanding of the concepts presented in class. It also includes reading the specific papers indicated by the teacher for later discussion in class.

 

 

 

Official assessment of learning outcomes

 

Assessment criteria and procedures
Written examination based on:

— Concepts explained in class.

— Lectures given by guest lecturers.

— Scientific papers analysed and discussed throughout the course.

The degree of active participation in all classes and general discussions will also be taken into account.

In order to pass the course, at least 70% of attendance is required, as well as passing the written examination.

 

Very important detail: Classes may be taught in English.