Teaching plan for the course unit



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General information


Course unit name: Tissue Engineering and Regenerative Medicine

Course unit code: 363753

Academic year: 2019-2020

Coordinator: Josep Maria Canals Coll

Department: Department of Biomedical Sciences

Credits: 6

Single program: S



Estimated learning time

Total number of hours 150


Face-to-face and/or online activities



-  Lecture





-  Group tutorial





-  Problem-solving class





-  Special practices





(7 practical activities, 4 groups, and 2-3 lecturers per activity.)


-  Seminar





-  Other class types




Supervised project


Independent learning




Competences to be gained during study



To be able to work independently (Personal).


To be able to work in a multilingual environment and communicate and transmit knowledge, procedures, results, abilities and skills (oral and written) in a native and a foreign language (Instrumental).


To gain an understanding of the interaction of engineering with other areas of knowledge (medicine, biology, biotechnology, pharmacy, veterinary science) and to be able to collaborate effectively in multidisciplinary teams, with a knowledge of the principles of complementary technologies.


To use systems for the search and retrieval of biomedical information and procedures for clinical data. To be able to understand and critically interpret scientific texts and their sources.


To gain knowledge of biomedical concepts and language.


To be able to conceive, design and produce implants and systems for tissue engineering equipment.


To know about and apply engineering concepts to the study of biological processes and the functions of the human organism. To gain knowledge of the atomic, molecular, cellular and organic levels of the physical mechanisms and phenomena that have an impact on health and disease.

Learning objectives


Referring to knowledge

— Understand the concept and possibilities of cell therapy and regenerative medicine.
— Differentiate cell sources for therapeutic strategies.
— Understand the protocols for cell cultures and acquire the capacity to do cell cultures.
— Understand different types of stem cells and their characteristics.
— Understand different types of adult stem cells according to their origin and potential.
— Understand the mechanisms of self-renewal and expansion.
— Understand pluripotent stem cells.
— Discover different mechanisms to obtain pluripotent stem cells.
— Understand the different sources of adult stem cells and their possible applications.
— Understand the concept of cellular niche.
— Understand different mechanisms of cell differentiation and their applications to stem cells.
— Learn the role of the physical environment in tissue engineering and regenerative medicine.
— Understand the effects of physical stimula in cell response.
— Understand the main types of scaffolds used in tissue regeneration.
— Understand the main types and methods of natural scaffold obtention used in organ and tissue regeneration.
— Understand the general principles of bioreactors in tissue engineering.
— Understand the specificities of bioreactors for different tissue and organ types.
— Learn the consolidated cell therapies and their exclusion from the law on drugs.
— Learn the advances in cell substitution and repair for different diseases.
— Understand protective therapies based on trophic factors.
— Become familiar with legislation on gene and cell therapy.
— Discover protocols and procedures used in translational research with gene and cell therapy.



Teaching blocks


1. Cell and gene introduction

1.1. Introduction to the subject

1.2. The cell, a brief review of cell structure and tissue formation

1.3. Gene expression: gene structure; Introduction to genome analysis

2. Stem cells and cell therapy

2.1. Advanced therapies: concepts and generalities

2.2. Cell therapy: concept and generalities

2.3. Consolidated therapies

2.4. Pluripotent stem cells

2.5. Adult stem cells

2.6. Stem cell differentiation and selection

2.7. Ex vivo gene therapy

2.8. Immunomodulatory and inflammatory cell therapy

2.9. Role of the physical environment in tissue engineering and regenerative medicine

2.10. Effects of physical stimula in cell response

3. Bioreactor production

3.1. General principles of bioreactors in tissue engineering

4. Scaffolds

4.1. Main types of artificial scaffolds used in tissue regeneration

4.2. Natural scaffold types and methods for organ and tissue regeneration

4.3. 3D bioprinting

5. Regenerative medicine

5.1. In vivo transplantation and monitoring;



Teaching methods and general organization



The teaching plan was designed to be taught in face-to-face lectures (maximum length, 50 minutes), seminars (maximum length, 50 minutes) and practice (1.5 hours each). Part of the programme is based on student independent work (self-learning) by doing research, oral and written presentations, self-assessing reports, etc.

Practical sessions

To take maximum advantage of face-to-face practical and problem sessions students should have already acquired the basic concepts presented during lectures. Besides, it is highly recommendable to have worked independently (alone or in groups) on the concepts and techniques already presented and available in the intranet for the subject.

Each practical or problem-solving session lasts between 1.5 and 2 hours.


Seminars are based on furthering the understanding of new therapeutic strategies and related aspects. Bibliographic material is provided, such as articles or updated reviews, which students must have read before the start of the seminar. Seminars require the active participation of students, as they are mostly structured around problem-based learning. At the end of each thematic block of seminars there will be short-answer questions or a brief test.

Tutored assignments

For supervised work, students present in groups of three or four students the research project on basic bioreactor processes they must have prepared and submitted in writing beforehand. These projects must be presented orally in front of the class and there is time for discussion. This activity is performed in English.



Official assessment of learning outcomes


Assessment of content, skills and competence acquisition is based on the following activities:

1.- Assessment of practical sessions is based on attendance and a short questionnaire at the end of each practice. Therefore, attendance to practical and problem sessions is essential in order to be assessed. This part is worth 10% of the global assessment of the subject.

2.- Assessment of seminars is based on students’ participation and a question related to the subject content at the end of each teaching block. Therefore, attendance to seminars and active participation is essential in order to be assessed. This part is worth 15% of the global assessment of the subject.

3.- Preparation and presentation of the research project on bioreactors. The first seminars are used to present problems on bioreactors in which students should work throughout the course. Students attend a practical session on the project on basic bioreactor processes mid-semester. This project is presented to the rest of the students and the lecturers at the end of the semester (10 minutes of presentation and 10 of discussion and defence). It represents 35% of the final grade.

4.- Final examination of 5 short-answer questions and/or numerical exercises. This includes the whole teaching blocks, lectures, seminars and practical sessions. This part is worth 40% of the final grade. A minimum of 30% of the grade must be obtained in order to pass the subject.

Students must take full advantage of the resources and tools used in the subject in order to acquire the competences and meet the objectives. Therefore, in addition to assessment systems, special credit is given for active class participation in theory, seminar and practical sessions.

Review of exams

A time will be set to consult the results obtained in the written examination in accordance with the established schedule and regulations.

Repeat assessment

Students who sit all the exams for the subject and fail to acquire the required knowledge, can repeat assessment, consisting of an examination with 5 short-answer questions on the whole contents of the course. In order to pass the subject, a minimum of 30% of the grade for the final exam must be obtained and an average grade of at least 5 must be achieved. The maximum grade for repeat assessment is “Pass”.


Examination-based assessment

A single examination of 15 short-answer questions including theory and practice.