Teaching plan for the course unit



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General information


Course unit name: Biomedical Microchips

Course unit code: 364596

Academic year: 2019-2020

Coordinator: Pedro Luis Miribel Catala

Department: Department of Electronic and Biomedical Engineering

Credits: 3

Single program: S



Estimated learning time

Total number of hours 75


Face-to-face and/or online activities



-  Lecture with practical component




Supervised project


(Activities indicated in the Virtual Campus.)

Independent learning






Stay updated with the documents available in the Virtual Campus and have it ready for theory and practical sessions.



Competences to be gained during study



To gain knowledge of basic and technological subjects required to learn new methods and technologies and ensure versatility and the ability to adapt to new situations (Personal).


To be able to work independently (Personal).


To use IT tools to search for reference resources or information related to medical technologies and bioengineering (Personal).


To be able to take further studies and to develop a positive attitude in order to keep knowledge up-to-date in a process of lifelong learning. To have sufficient depth of knowledge to start postgraduate studies in the field of advanced biomedical engineering.

Learning objectives


Referring to knowledge

— Learn about the concept of biochip and get to know the wide range of devices related to the field.
— Learn the process of design of a microelectronic e-device in the biomedical field, from the conception of the idea to the final implementation, through the use of examples. This objective is met through a progressive programme for the subject in relation to knowledge.
— Acquire basic knowledge on CMOS technology.
— Get to know the bases for analog microelectronic design and introduce mixed microelectronic design. From these bases, electronics are combined with their integration to related elements, such as biosensors for different applications: for example, an introduction to biosensors and their applications to Point-of-Care, the concepts of on-body and implantable devices, and image sensors.
— Introduce the problems related to biocompatibility. The introductory nature of this subject is apparent. Starting from a project to be developed as backbone to the course, the bases of the subject are furthered to move into the specialised section.


Referring to abilities, skills

— Work independently and in groups, research specific information, complete electronic designs, etc. Independent work should be well organised: preparation of materials, reading (scheduled book chapters, articles, etc.); students must stay updated in task programming, etc.



Teaching blocks


1. Introduction; What are biochips?

*  What are biochips? Typologies; Needs; Fields and applications; Introduction to Point-of-Care (POC); Discrete and integrated examples; Concepts of body sensor networks; Wearables; Implantable; Other examples

2. Technology

1.1. Introduction to CMOS process and MOSFET transistors

1.2. Electric model; Operating regions; Small signal / Electric model; Operating regions; DC and AC analysis

1.3. Introduction to ASIC technologies design and manufacture / Introduction to ASIC technologies

3. Introduction to CMOS analog circuits

2.1. Basic CMOS modules

2.2. Basic, single-ended and differential CMOS amplifiers

2.3. Filters

2.4. Comparators

2.5 Concepts related to energy harvesting and power-management

4. Digitisation of analog signals and treatment of noise / Fundamentals in mixed-signals design

4.1. Noise

4.2. Introduction to ADCs

5. Sensors; Cross-disciplinary blocks during the course

6. Examples; Cross-disciplinary topic

Development of POC platforms

Examples of implantable technologies

Other examples; BioCHIPS

7. Cross-disciplinary project during the course



Teaching methods and general organization


Classes combine theory and practice. Independent work and staying up-to-date are important. 

Face-to-face sessions.

Classes are taught preferably in English.

The activities are set in relation to the reading material scheduled (transparencies, articles, book chapter, etc.), before and after each session, resolution of questionnaires, programmed group assignments, problem-solving activities, etc.

The same project is planned within a known simulation environment, such as SPICE.



Official assessment of learning outcomes


The subject has a heavy work load besides class hours, so that the continuous assessment is calculated from:

— reading reviews, summaries and collaboration in the classroom (30-40%)
— a project submitted during the course (40%)
— final examination (10-20%)

Activities are set in reading programmes, before the sessions, the material prepared (transparencies, articles, etc.), questionnaires completed in class, group assignments, etc. The same project is planned within a known simulation environment, such as SPICE.


Examination-based assessment

Students must present the project for the subject and the tasks determined by the lecturer. The grade is obtained from the final examination (60%) and the project (40%).



Reading and study resources

Consulteu la disponibilitat a CERCABIB


A CMOS Self-Powered Front-End Architecture for Subcutaneous Event-Detector Devices: Three-Electrodes Amperometric Biosensor Approach.

J. Colomer-Farrarons and P. Miribel-Català

Publication Date: February 25, 2011 | ISBN-10: 9400706855 | ISBN-13: 978-9400706859 | Edition: 2011


Llibres fonaments disseny / Design books

CMOS Circuit Design, Layout, and Simulation, 3rd Edition (IEEE Press Series on Microelectronic Systems)

R. Jacob Baker.

Publication Date: September 7, 2010 | ISBN-10: 0470881321 | ISBN-13: 978-0470881323 | Edition: 3


Llibres fonaments disseny / Design books

Fundamentals of Microelectronics

B. Razavi.

Publication Date: January 28, 2008 | ISBN-10: 0471478466 | ISBN-13: 978-0471478461 | Edition: 1


Llibre de fonaments / Fonamentals

Microelectronic Circuits (The Oxford Series in Electrical and Computer Engineering)


Publisher: Oxford University Press, USA; 6 edition (December 15, 2009)

Language: English| ISBN-10: 0195323033 | ISBN-13: 978-0195323030



Farem referència a diferents materials disponibles en format OPENSOURCE (INTECH).

Alguns exemples:







Farem diferents referències a material disponible via l’IEEE que pot ser visualitzat des d’ordinadors amb IP de la UB.


Electronic text

Hi haurà transparències pròpies per a l’assignatura, disponibles via el Campus Virtual.