Teaching plan for the course unit

 

 

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General information

 

Course unit name: Translational Research and Therapy in Cancer

Course unit code: 569896

Academic year: 2021-2022

Coordinator: Nieves Agell Jane

Department: Faculty of Medicine

Credits: 6

Single program: S

 

 

Estimated learning time

Total number of hours 150

 

Face-to-face and/or online activities

50

 

-  Group tutorial

Face-to-face and online

 

15

 

(4 groups )

 

-  Special practices

Face-to-face and online

 

20

 

(4 groups )

 

-  Seminar

Face-to-face and online

 

15

 

(4 groups)

Supervised project

50

Independent learning

50

 

 

Learning objectives

 

Referring to knowledge

— Acquire an overview of translational research and current therapies applied to tumours with a higher incidence, such as colon, breast, lung, melanoma, pancreatic, glioma, leukaemia and lymphoma, among others.

 

— Acquire the tools to understand new approaches to cancer diagnosis and therapy as based on the students’ knowledge of molecular and cellular mechanisms of tumorigenesis.

 

 

Teaching blocks

 

1. Colorectal cancer (Clínic)

1.1. Prevention: Epidemiology of CRC; CRC screening strategies

1.2. Prevention: Genetics of CRC; Family and hereditary forms

1.3. Prevention: Genetic counselling; CRC committee

1.4. Prevention: Research in preventing CRC; Mutational analysis, susceptibility to cancer, biomarkers.

1.5. Diagnosis: Advanced endoscopic techniques

1.6. Diagnosis: Histology of CRC; Morphological and molecular techniques

1.7. Treatment: Biological bases of cancer treatment

1.8. Treatment: Multidisciplinary treatment of CRC

1.9. Treatment: Multidisciplinary management of CRC; Committee of tumors

1.10. Treatment: Experimental surgery of CRC

2. Breast cancer (Clínic)

2.1. Incidence and epidemiology

2.2. Pathophysiology and tumor development

2.3. Anatomical pathology

2.4. Molecular subtypes

2.5. Diagnostic radiology: Mammography

2.6. Diagnostic radiology: Nuclear medicine

2.7. Breast surgery

2.8. Surgical treatment of axillary lymph nodes

2.9. Systemic treatment

2.10. Radiotherapy 

2.11. Clinical trials and new therapies

2.12. Clinical case discussion

2.13. Visit to laboratory

3. Leukaemias and lymphomas (Clínic)

3.1. Classification of hematologic malignancies

3.2. Mechanisms of leukaemiagenesis

3.3. Diagnostic methods

3.4. Treatment: From chemotherapy to targeted therapy

3.5. Chronic myeloid leukaemia: A model of success

3.6. Acute lymphoblastic leukaemia

3.7. Acute myeloid leukaemia

3.8. Multiple myeloma and monoclonal gammopathies

3.9. Microenvironment in lymphoma

3.10. Diffuse large B-cell lymphoma 

3.11. Follicular lymphoma and mantle cell lymphoma

3.12. Chronic lymphocytic leukaemia and monoclonal B lymphocytosis

3.13. Sequencing and methylation in CLL

3.14. Mechanisms of transformation in lymphomas

3.15. Lymphoma and immunodeficiency

3.16. Clinical cases of leukaemia

4. Melanoma (Clínic)

4.1. Melanoma: Epidemiological and clinical aspects 

4.2. New strategies for melanoma diagnosis

4.3. Histopathology of melanoma and new mollecular techniques for diagnosis

4.4. Somatic alterations in melanoma

4.5. Target therapies in melanoma

4.6. Nevus, melanoma and UV

4.7. Immunology, cell therapy and melanoma

4.8. Genetic counselling in melanoma

4.9. Family melanoma; Main genes involved

4.10. Personal experience as predoctoral student specializing in melanoma

5. Brain tumors (Clínic)

5.1. Overview

5.2. Neuropathology of brain tumors

5.3. Diagnostic neuroradiology  

5.4. Surgical treatment

5.5. Molecular aspects of gliomas

5.6. Treatment of low-grade glioma

5.7. Treatment of high-grade glioma

5.8. Management of brain metastases

5.9. Pediatric brain tumors: Overview, medulloblastoma, malignant astrocytoma, low-grade astrocytoma and ependymoma

6. Pediatric cancer (HSJD)

6.1. Overview; Epidemiology

6.2. Diagnosis and molecular biology

6.3. Leukaemia

6.4. Lymphoma

6.5. Neuroblastoma

6.6. Embryonic tumors (Wilms, hepatoblastoma, Rabdoide)

6.7. Medulloblastoma and embryonic

6.8. DIPG /HGG

6.9. Pilocytic astrocytoma, ependymoma

6.10. Soft tissue sarcomas

6.11. Bone sarcomas

6.12. Retinoblastoma; Family cancer

6.13. Pharmacology

7. Digestive cancer (ICO)

7.1. Colon: Introduction to epidemiology, pathology, diagnosis, prognosis, therapy, clinical trials

7.2. Pancreas: Introduction to epidemiology, pathology, diagnosis, prognosis, therapy, clinical trials

7.3. Esophageal-gastric: Introduction to epidemiology, pathology, diagnosis, prognosis, therapy, clinical trials

7.4. Clinical sessions

7.5. Functional committee

8. Lung cancer (ICO)

8.1. Functional committee

8.2. Introduction to epidemiology, pathology, diagnosis, prognosis, therapy, clinical trials

8.4. Supplementing information with bibliographic material; Self-learning activities

8.5. Clinical sessions

9. Breast cancer (ICO)

9.1. Incidence, risk factors and stages of breast cancer

9.2. Radiotherapy for breast cancer

9.3. Supplementing information with bibliographic material; Self-learning activities

9.4. Clinical sessions

9.5. Functional committee

10. Lung cancer (Clínic)

11. Prostate cancer (Clínic)

 

 

Teaching methods and general organization

 

This course consists of a series of thematic sections, each corresponding to a different type of tumour. Students have to choose three of these blocks.

Within each block oral communicative practices and tutorials will be scheduled to study:  

— Incidence, pathophysiology, tumour development, pathology, diagnosis, prognosis, therapy (current clinical trials, future therapies), current research, etc. for the specific tumour type. 

Some of these sections will also include some of the following activities:

— Attendance to (or simulation of) clinical committees

— Analysis of clinical cases

— Visit to the research laboratory