Teaching plan for the course unit



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General information


Course unit name: New Therapies and Translational Research in Metabolic Diseases

Course unit code: 569900

Academic year: 2021-2022

Coordinator: Manuel Vazquez Carrera

Department: Faculty of Medicine

Credits: 3

Single program: No definit



Estimated learning time

Total number of hours 75


Face-to-face and/or online activities



-  Lecture

Face-to-face and online




-  Document study

Face-to-face and online




-  Student presentation and discussion

Face-to-face and online




-  Seminar

Face-to-face and online



Supervised project


Independent learning






The course is taught in English or Spanish depending on the lecturer. Articles and class materials are written in English. Students are expected to have a level of proficiency in English that enables them to understand scientific articles, and basic oral (conversational) and writing skills to engage in course discussions or make oral presentations of scientific literature.

Previous training
Classes have an advanced level, with an emphasis on the analysis of biological processes from a molecular, biochemical, cellular and therapeutic perspective. Students are expected to demonstrate a knowledge on cell biology, molecular genetics, biochemistry and pharmacology equivalent to the level achieved with a university degree in Biology, Pharmacy, Biochemistry or Medicine.



Competences to be gained during study


General competences

— Ability to acquire, critically process and communicate specific information, and ability to propose and discuss different hypotheses.

— Ability to outline and design experimental, theoretical or numerical approaches to solve specific questions.


Specific competences

— Ability to describe major mechanisms, networks and pathways involved in the treatment of obesity, diabetes and atherosclerosis.





Learning objectives


Referring to knowledge

— Understand the cellular and molecular mechanisms involved in the treatment of obesity, diabetes and atherosclerosis.

Referring to skills, abilities

— Acquire the ability to communicate scientific information both orally and in written form. 
— Acquire skills in the search for scientific information and an ability to organize, integrate and connect this information.
— Acquire the ability to reason, deduct and critically analyse scientific research.

Referring to attitudes, values and norms

— Promote work in cooperative groups.
— Promote leadership and decision making skills.
— Promote self-criticism as a working tool and constructive criticism in relation to others.



Teaching blocks


1. Treatment of obesity

1.1. Global treatment strategies: the "pyramid" of obesity treatment; Treatment of obesity versus treatment of its side effects
1.2. Dietary treatment of obesity: low calorie diets, ketogenic diets, etc; Exercising and obesity
1.3. Pharmacological treatment of obesity; Historical development of anti-obesity drugs; Drug action on hunger / satiety system, absorption of nutrients and energy expenditure
1.4. Surgical treatment of obesity: bariatric surgery; Endocrine and metabolic bases of the effects of bariatric surgery; Other surgical strategies
1.5. Seminar: RIMONABANT: history of a failed anti-obesity drug

2. Treatment of diabetes

2.1. Diet and physical activity
2.2. Novel approaches in the treatment of type 1 diabetes mellitus
2.3. Insulin treatment
2.4. Oral anti-diabetic drugs
2.5. Novel approaches in the treatment of type 2 diabetes mellitus

3. Treatment of atherosclerosis

3.1. Diet and plasma lipids: dietary control of dyslipidemia
3.2. Drugs and dyslipidemia; Molecular targets for hypolipidemic drugs
3.3. Investigational drugs in the control of hypercholesterolemia and diabetic dyslipidemia



Teaching methods and general organization


This course is part of a master’s degree with a clear orientation towards PhD studies. The course consists of a combination of introductory lectures and presentations by students. Students are understood to have different experience and background.



Official assessment of learning outcomes


General criteria
— Attendance and participation in debates
— Examination

Specific criteria
The specific criteria will be explained on the first day of class.


Examination-based assessment

General criteria
— Attendance and participation in debates
— Examination

Specific criteria
The specific criteria will be explained on the first day of class.



Reading and study resources

Consulteu la disponibilitat a CERCABIB


Reviews in magazines:
International Journal of Obesity (www.nature.com/ijo/)
Obesity (http://www.obesity.org/publications/obesity-journal.htm)
Obesity reviews (http://onlinelibrary.wiley.com/journal/10.1111/ 28ISSN%% 291467-789X)
Cell Metabolism (www.cell.com/cell-metabolism/)
Endocrinology (http://endo.endojournals.org/)
Nature Reviews Endocrinology (http://www.nature.com/nrendo/index.html)

Comprehensive electronic resources and basic textbooks recommended:
— Sociedad Española de Diabetes (SED)
— European Society for the Study of Diabetes (EASD)
— American Diabetes Association (ADA)
— Type 2 Diabetes Mellitus. Manuel Serrano Ríos y José A. Gutiérrez Fuentes. Elsevier. Biblioteca Fundación Lilly (free).